√ Tgif: Stem Cell Weekend Reads Links

Here are some stem cell weekend reads for your enjoyment along with various links and headlines.

Some science pubs that caught my eye:

Paul, et al. Figure 2G-J Science

• Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model


• High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain


• Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human


• Tracing the origins of relapse in acute myeloid leukaemia to stem cells


• Hypothalamic regulation of regionally distinct 4dukt neural stem cells and neurogenesis

There’s been a burst of stem cell policy papers recently focused on stem cell clinics that directly market unproven offerings to patients. These papers highlight what a mess we are all in within the stem cell field with a stem cell clinic industry that has run wild.

• Marketing of unproven stem cell–based interventions: A call to action by Sipp, Rasko, Caulfield, and colleagues.

and a duo of important, recent papers by Leigh Turner:

• On Clinicaltrials.gov featured here in the WaPo


• And then one from a few weeks back on stem cell court cases

Various news headlines:

• Innate reaction of hematopoietic stem cells to severe infections


• ‘Nano-in-micro’ stem cell delivery could rescue blood flow after injury


• Baby Boomers turn to stem cells for help with painful joints


• Stem cell ads: Promise much, deliver little

And this important, but not exactly good news story from RetractionWatch about a stem cell scientist Susana Gonzalez facing retraction of papers and more.

Any more stem cell weekend reads you can suggest?

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√ Top Tgif Stem Cell Weekend Reads Of Papers News

Modified Wikipedia image

Bulls-eye! Here are some stem cell weekend reads including both interesting new papers & news headlines.

Of course, this week also had stem cell awareness day and I wrote about 10 key issues for the field for the coming 10 years!

Weekend reads

Papers

• Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human 


• A simple and versatile system for the ATP-dependent assembly of chromatin


• Genetic Evolution of Glioblastoma Stem‐like Cells from Primary to Recurrent Tumor


• MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux


• Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma


• Gene Editing in Rat Embryonic Stem Cells to Produce In VitroModels and In Vivo Reporters


• The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins

News

• Stem cell baldness cure? USC stem cell scientists developing a new cure-all for baldness


• Most versatile ever?! Most versatile stem cell ever may help us understand miscarriage


• Paolo Macchiarini dodges a bullet. Sweden won’t prosecute Italian stem cell scientist


• This thing’s name is kinda cringy Scientists create ‘tooth cracker’ device to harvest stem cells


• You got guts kid. Scientists used human stem cells to build a new rat intestine


• Indian government bans some stem cell banking. Govt bans commercial banking of stem cells

Did I miss any of your stem cell weekend reads? Let us know in the comments.

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√ Reading List Of Recent Stem Cell Pubs Headlines

2018 has started quickly on the stem cell and regenerative medicine research front with many interesting new papers and a lot of headlines. You can see my predictions for this year here.

Gupta, et al. Stem Cell Reports 2018 Figure 6

Below is a list of some of the more notable papers and striking news headlines. Note that just because I listed a news headline doesn’t mean a fan and in some cases below I include some words of commentary. I’ve also thrown in a few more rando papers of interest to me.

Recent interesting papers

Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells (see part of Fig. 6 above).

Light-focusing human micro-lenses generated from pluripotent stem cells model lens development and drug-induced cataract in vitro

DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells

Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly Use Intracellular Energy Reserves Through Glycolysis Explains Poor Cell Survival After Implantation

A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

Mentoring the Next Generation: Brigid Hogan

Towards stem cell based therapies for Parkinson’s disease

Developmental biology, the stem cell of biological disciplines

Recent stem cell headlines

New Blood Stem Cell Harvest Method Could Speed Up Transplants

Should California Voters OK $5 Billion More for Stem Cell Research? (CIRM’s future)

Stem Cells for Knee Problems? U.S. Doctors Investigate (WSJ flubbed this article in some important ways including wrongly saying FDA condones certain stem cell treatments including using fat stem cells. Uh, no. Plus, article didn’t have needed scientific balance of views.)

This Doctor’s Revolutionary Stem Cell Treatments Could Eradicate HIV (interesting Daily Beast piece, but overly aspirational title).

Seattle Cancer Care Alliance Survival Rates among Top in U.S. for Fred Hutch Bone Marrow Transplant Program at SCCA

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√ Recent Stem Cell Pubs News: Reprogramming, Chromatin, Single-Cell, Astellas, More

Screenshot from news article in Yomirui Shimbun on IPS cell-based organ production in pigs.

What new papers and news in the stem cell sphere caught your eye? Here are some recent items that seem notable to me.

• Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. This paper reports cellular reprogramming to insulin-producing cells in mice. They reprogrammed α-cells with Pdx1 and MafA proteins.


• ‘Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease’ in Nature Neuroscience. Using IPS cells for insights.


• “What open chromatin features predict pluripotency?” asked and answered by the authors of this review in Developmental Cell: Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency.


• Over at the journal Stem Cells, this piece highlights the utility of single cell approaches. Single‐Cell Transcriptomics of Human Mesenchymal Stem Cells Reveal Age‐Related Cellular Subpopulation Depletion and Impaired Regenerative Function.


• Over at the CIRM Blog student Pallavi Penumetcha has a nice piece on new, partially CIRM-supported research on a cool model of human oligodendrocyte maturation.


• Commenter Bill points out two signs of progress with Astellas’ regenerative medicine efforts led by Bob Lanza (formerly Ocata/ACT’s regenerative medicine clinical pipeline.


• David Jensen over at his blog California Stem Cell Report has news of a new bill working toward a stricter California state law on stem cell clinics.


• Researchers to use iPS cells to make human pancreases inside pigs. See image above from newspaper article.

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